Endocrine Abstracts

We describe a case of severe rhabdomyolysis(peak CK 48897 μ/ml and massive myoglobinuria) complicating hyperglycemic hyperosmolar coma. A 57y/o M with DM2 on metformin presented with polyuria, polydipsia, weakness and confusion. On admission he had GCS E2M3V1 no signs of trauma or infection. Na 137 mEq/l K 4.8 mEq/l HCO3 22 mEq/l Cl 93 mEq/l BUN 116 mg/dl Cr 3.2 mg/dl glucose 1710 mg/dl pH 7.22 ketones +small, Mg 5.2 mg/dl P 3.3 mg/dl Ca 9.6 mg/dl TSH 1.47 &#95...

We describe a case of aggressive pituitary adenoma with atypical biological behavior treated with surgery radiation & chemotherapy. A 46 y/o F presented with nausea & acute vision loss R>L,with no symptoms of amenorrhea, hypothyroidism or hypoadrenalism. Brain MRI showed 4.7×3.6×3.6 cm pituitary macroadenoma with mass effect on optic chiasm, cavernous sinus extension, internal carotid artery encasement, extension into R foramen ovale, orbital apex, spheno...

Introduction: Sarcoidosis is a multisystem noncaseating granulomatous disease with prevalence of 40/100 000. One percent of patients with sarcoidosis have isolated neurosarcoidosis, few cases involve the hypothalamus/pituitary (65 reported cases from 2002 to 2014). We present a case of hypothalamic-pituitary sarcoidosis with hypothermia (one case reported between 2002 and 2014), leptomeningitis, diabetes insipidus and pan-hypopituitarism.Case report: Fam...

Introduction: Calcium metabolism during pregnancy changes significantly but ionized calcium level remains normal. During pregnancy, there is two-fold increase in intestinal calcium absorption mediated by increase in 1,25-dihydroxyvitamin D. Hypercalcemia in pregnancy is uncommon and most reported cases are primary hyperparathyroidism.Case report: A 18-year-old 10 weeks’ pregnant African American female presented to hospital with epigastric pain, nau...

Our previous work has shown that the intake of a high fat high carbohydrate (HFHC) meal results in an increase in endotoxin (LPS) and LPS binding protein (LBP) concentrations concomitant with an increase in the expression of TLR-4, the receptor for LPS, and CD-14, which facilitates the binding of LPS to its receptor. In addition, there is an increase in ROS generation, NFkB binding and the expression of TNF-α and IL-1β. Our work has also demonstrated that an equicalo...

We present a 57-year-old female with Cushing’s syndrome characterised by new type 2 diabetes, hypertension, weight gain, bruising, proximal myopathy and depression. She also had poorly-healing cellulitic ulcers on both legs. Investigations: hypokalaemia and ACTH-dependent Cushing’s syndrome. Low dose dexamethasone suppression test: T=0 ACTH 85 ng/l, cortisol 907 nmol/l, T=48 h cortisol 807. High dose dexamethasone suppression test failed to suppr...